Heat oven to 375ยบ
Tear the piece of bread into pieces and place in a bowl. Pour the buttermilk over the bread pieces and allow it to soak.
Put ground beef, egg, mustard, worcestershire sauce, garlic powder, onion powder, Italian seasoning, salt and pepper in a large bowl. Add soft milk soaked bread. Gently massage meat just until combined.
Heat a large oven safe skillet (I prefer cast iron) over high heat and place a quarter size portion of the meat mixture in the pan and cook just until cooked through. Taste the meat and make any adjustments to the seasonings.
Turn heat down to medium. Working quickly make small meatballs (about 30g each) and place in the hot skillet leaving about an inch of room around each meatball.
Place pan in oven and bake for 10-15 min or until the tops of the meatballs no longer look pink and start to brown.